It has been speculated so much that we just take it as fact at this point. But there has not been a solid confirmation that The Lizard is the main villain of The Amazing Spider-Man until right this very second. Actor C. Thomas Howell recently appeared on The Retroradio, and he confirmed that the Lizard will battle Peter Parker, and that his character's son is involved in the choas. Here is what C. Thomas Howell had to say about how his character plays a part in one of The Amazing Spider-Man's most important scenes. "There is not a whole lot to talk about. Sony wants us to be hush-hush right now. I play a relatively small role. I play a construction worker who's son is caught in the middle of a battle between the Lizard and Spider-Man on the Manhattan bridge. Spider-Man helps me get my son back from this perilous situation. There is some payback there at the end of the movie. Spider-man is kind of hurting. I help him when all of the other people won't. Part